Pulse radiolysis studies of several analogues of 1,8-dihydroxy-9-anthrone (anthralin) under various conditions
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چکیده
منابع مشابه
SYNTHESIS OF 1, l1-DIHYDROXY-2,2'- (THIODIMETHYLENE) BIS-9(1 OH)-ANTHRONE
An efficient synthesis of the 1,l'-dihydroxy-2,2'-(thiodimethy1ene)bis-9(10H)- anthrone (5) is described. Reaction of 1 -methoxy-2-(bromomethy1)-9,lOanthraquinone (1) with excess sodium sulfide in ethanol, demethylation to the corresponding hydroxy and subsequent selective reduction produced the title compound in high yield.
متن کاملMulti-bromination of 1,8-dihydroxy-9- anthrone, important intermediates in the synthesis of antipsoriatic drugs
10-bromo-1,8-dihydroxy-9-anthrone (10-bromoanthralin) was synthesized with precise ratio of bromine to anthralin (1.10:1), respectively. With this ratio of the reagents, the reaction is repetitive at any scale. This compound is a highly significant intermediate for the synthesis of many anthralin derivetised antipsoriatic drugs. Bromination at both benzylic and aromatic ring positions of anthra...
متن کاملsynthesis of 1, l1-dihydroxy-2,2'- (thiodimethylene) bis-9(1 oh)-anthrone
an efficient synthesis of the 1,l'-dihydroxy-2,2'-(thiodimethy1ene)bis-9(10h)- anthrone (5) is described. reaction of 1 -methoxy-2-(bromomethy1)-9,loanthraquinone (1) with excess sodium sulfide in ethanol, demethylation to the corresponding hydroxy and subsequent selective reduction produced the title compound in high yield.
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Superoxide reductases (SORs) are small metalloenzymes, which catalyze reduction of O2*- to H2O2. The reaction of the enzyme from Treponema pallidum with superoxide was studied by pulse radiolysis methods. The first step is an extremely fast bi-molecular reaction of the ferrous center with O2, with a rate constant of 6 x 10 (8) M(-1) s(-1). A first intermediate is formed which is converted to a ...
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The chemical stability of repository compounds is affected by various environmental conditions during long-term storage. Studies were carried out to evaluate the effects of the following potential causes of instability of compounds in DMSO at a 10-mM concentration: water, oxygen, freeze/thaw cycles, and storage container material. A set of compounds was selected for the study based on structura...
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ژورنال
عنوان ژورنال: Journal of Current Pharma Research
سال: 2010
ISSN: 2230-7834,2230-7842
DOI: 10.33786/jcpr.2010.v01i01.004